期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 80, 期 9, 页码 4566-4572出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00420
关键词
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资金
- FSE
- Junta de Castilla y Leon [GR178]
- JCyL-FSE
- EU Research Potential [FP7-REGPOT-2012-CT2012-31637-IMBRAIN]
- European Regional Development Fund (FEDER)
- Spanish Instituto de Salud Carlos III [PI11/00840]
Sesterterpenes with a salmahyrtisane skeleton have been synthesized for the first time. (-)-Sclareol has been selected as a precursor for the synthesis of two novel natural products: salmahyrtisol A (1) and hippospongide A (2). Our results represent a biomimetic approach to obtaining salmahyrtisanes from hyrtiosanes. Salmahyrtisol A has shown an activity comparable to that of the standard anticancer drugs in the cell lines A549, HBL-100, HeLa, and SW1573.
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