期刊
DEVELOPMENT
卷 135, 期 19, 页码 3175-3183出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.018697
关键词
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资金
- Biotechnology and Biological Sciences Research Council
- Engineering and Physical Sciences Research Council
- EPSRC [EP/F005873/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/F005873/1] Funding Source: researchfish
Positional specification by morphogen gradients is traditionally viewed as a two-step process. A gradient is formed and then interpreted, providing a spatial metric independent of the target tissue, similar to the concept of space in classical mechanics. However, the formation and interpretation of gradients are coupled, dynamic processes. We introduce a conceptual framework for positional specification in which cellular activity feeds back on positional information encoded by gradients, analogous to the feedback between mass-energy distribution and the geometry of space-time in Einstein's general theory of relativity. We discuss how such general relativistic positional information (GRPI) can guide systems-level approaches to pattern formation.
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