期刊
DEVELOPMENT
卷 135, 期 4, 页码 659-667出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.013623
关键词
angiogenesis; netrin; placenta; UNC5B; zebrafish; mouse
资金
- NEI NIH HHS [R01 EY012873, R01EY12873] Funding Source: Medline
- NHLBI NIH HHS [R01 HL068873, R01 HL077671-03, R01 HL084516-01A1, R01 HL077671, R01 HL084516] Funding Source: Medline
There is emerging evidence that the canonical neural guidance factor netrin can also direct the growth of blood vessels. We deleted the gene encoding UNC5B, a receptor for the netrin family of guidance molecules, specifically within the embryonic endothelium of mice. The result is a profound structural and functional deficiency in the arterioles of the placental labyrinth, which leads first to flow reversal in the umbilical artery and ultimately to embryonic death. As this is the only detectable site of vascular abnormality in the mutant embryos, and because the phenotype cannot be rescued by a wild-type trophectoderm, we propose that UNC5B-mediated signaling is a specific and autonomous component of fetal-placental angiogenesis. Disruption of UNC5B represents a unique example of a mutation that acts solely within the fetal-placental vasculature and one that faithfully recapitulates the structural and physiological characteristics of clinical uteroplacental insufficiency. This pro-angiogenic, but spatially restricted requirement for UNC5B is not unique to murine development, as the knock-down of the Unc5b ortholog in zebrafish similarly results in the specific and highly penetrant absence of the parachordal vessel, the precursor to the lymphatic system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据