期刊
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
卷 138, 期 41, 页码 2084-2088出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0033-1349608
关键词
pancreatic cancer; thrombosis; heparin; primary prevention
Background and objective: The indication for medical venous thrombosis prophylaxis in ambulatory cancer patients is still under discussion. To provide more data on this topic we conducted an analysis in ambulatory patients with advanced pancreatic adenocarcinoma, reflecting a patient cohort at high risk of symptomatic venous thromboembolism (sVTE). Patients and methods: Data from 312 consecutively recruited patients of the CONKO-004 trial were analysed according to pre-defined parameters and additionally with respect to established scores. To focus on patients with highest risk of sVTE unvaried and multivariate analyses were conducted. Results: The global analyses had educed a number needed to treat (NNT) by medical thrombosis prophylaxis of 12 patients to prevent one sVTE. The modified score model did not provide further clinical benefit. However, the regression model can identify single parameters with a trend to higher risk of sVTE or higher risk of severe bleeding. Most of the parameters do not have enough power to be significant, but they can support clinical decisions. Conclusion: These data suggest that medical thrombosis prophylaxis should be performed in patients with advanced pancreatic cancer at least for the initial 3 months of first line chemotherapy.
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