4.7 Article

Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Trifluoromethyldihydropyridinones

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JOURNAL OF ORGANIC CHEMISTRY
卷 80, 期 11, 页码 5900-5905

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AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.5b00232

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资金

  1. Ministry of Science and Technology of China [2011CB808600]
  2. National Science Foundation of China [21272237]

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The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of alpha-chloroaldehydes and trifluoromethyl N-Boc azadienes was developed, giving the corresponding 3,4-disubstituted-6-trifluoromethyldihydropyridin-2(1H)-ones in good yields with exclusive cis-selectivities and excellent enantioselectivities.

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