期刊
DERMATOLOGY
卷 219, 期 1, 页码 42-47出版社
KARGER
DOI: 10.1159/000212118
关键词
Small- to medium-sized pleomorphic T-cell lymphoma; Cutaneous T-cell lymphoma; T-cell pseudolymphoma
类别
Background: Solitary skin nodules composed of pleomorphic T lymphocytes are often the source of diagnostic problems. Objective: To characterize the clinicopathological features, prognosis and optimal treatment modalities of patients with solitary lymphoid nodules of small-to medium-sized pleomorphic T lymphocytes. Methods: Twenty-six patients were analysed for clinical, histopathological, immunophenotypical, molecular and follow-up data. Results: Lesions were located mainly on the head and neck (n = 16; 61.5%) or trunk (n = 8; 30.8%). Histopathology showed nonepidermotropic nodular or diffuse infiltrates of small-to medium-sized pleomorphic T lymphocytes. Monoclonality was found by PCR in 54.2% of cases (n = 13/24). After a mean follow-up of 79.7 months, a local recurrence could be observed only in 1 patient. Conclusions: Our patients have a specific cutaneous lymphoproliferative disorder characterized by reproducible clinicopathological features. The incongruity between the indolent clinical course and the worrying histopathological features poses difficulties in classifying these cases unambiguously as benign or malignant. We suggest to describe these lesions as 'solitary small-to medium-sized pleomorphic T-cell nodules of undetermined significance'. Irrespective of the name given to these equivocal cutaneous lymphoid proliferations, follow-up data support a non-aggressive therapeutic strategy. Copyright (C) 2009 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据