期刊
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
卷 61, 期 3, 页码 247-254出版社
CENTER ACADEMIC PUBL JAPAN
DOI: 10.3177/jnsv.61.247
关键词
dietary fat; food palatability; opioid system; olfactory nerve; glossopharyngeal nerve
资金
- JSPS KAKENHI Grant [25292071, 24688014]
- Science and technology research promotion program for agriculture, forestry, fisheries and food industry
- Grants-in-Aid for Scientific Research [24688014] Funding Source: KAKEN
High-fat foods tend to be palatable and can cause addiction in mice via a reinforcing effect. However, mice showed preference for low fat concentrations that do not elicit a reinforcing effect in a two-bottle choice test with water as the alternative. This behavior indicates the possibility that the mechanism underlying fat palatability may differ depending on the dietary fat content. To address this issue, we examined the influences of the opioid system and olfactory and gustatory transductions on the intake and reinforcing effects of various concentrations of a dietary fat emulsion (Entralipid). We found that the intake and reinforcing effects of fat emulsion were reduced by the administration of an opioicl receptor antagonist (naltrexone). Furthermore, the action of naltrexone was only observed at higher concentrations of fat emulsion. The intake and the reinforcing effects of fat emulsion were also reduced by olfactory and glossopharyngeal nerve transections (designated ONX and GLX, respectively). In contrast to naltrexone, the effects of ONX and GLX were mainly observed at lower concentrations of fat emulsion. These results imply that the opioid system seems to have a greater role in determining the palatability of high-fat foods unlike the contribution of olfactory and glossopharyngeal nerves.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据