期刊
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
卷 61, 期 2, 页码 201-204出版社
CENTER ACADEMIC PUBL JAPAN
DOI: 10.3177/jnsv.61.201
关键词
epimedium herb; anti-androgenic activity; icarisid II; flavonoid glycoside
Anti-androgens are regarded as potential therapeutic agents for the treatment of prostate cancer. We determined that an epimedium herb (EH) extract exhibited anti-androgenic activity in a luciferase assay using androgen receptor-positive prostate cancer LNCaP cells. Nine EH-derived flavonoids were examined. The results identified icarisid II as a very potent anti-androgenic EH-derived flavonoid. A quantitative RT-PCR analysis confirmed that the flavonol suppressed the expression of the androgen-responsive KLK3 gene.
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