期刊
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
卷 26, 期 12, 页码 1540-1546出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jnutbio.2015.07.025
关键词
Bone; Calcium; CLA; Obesity; Osteocalcin
资金
- EU-funded project [BIOCLAIMSFP7-244995]
- Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion, CIBERobn
- Conselleria d'Educacio, Cultura i Universitats, Govern de les Illes Balears
- European Social Fund
- [AGL2012-33692]
The potential of conjugated linoleic acids (CIA) and calcium in weight management in animal models and human studies has been outlined, as well as their use to prevent bone loss at critical stages. In addition, it has been suggested that bone remodeling and energy metabolism are regulated by shared pathways and involve common hormones such as leptin. We have previously shown that supplementation with CLA and calcium in adult obese mice decreases body weight and body fat. The aim of the present study was to assess the effects of these two compounds on bone and energy metabolism markers on bone. Mice (C57BL/6J) were divided into five groups according to diet and treatment (up to 56 days): control (C), high-fat diet (HF), HF+CLA (CIA), HF+calcium (Ca) and HF with both compounds (CLA+Ca). At the end of treatment, bone formation markers were determined in plasma and expression of selected bone and energy markers was determined in tibia by quantitative polymerase chain reaction. Results show that CIA was associated with decreased tibia weight and minor impact on bone markers, whereas calcium, either alone or co-supplemented with CIA, maintained bone weight and promoted the expression of bone formation genes such as bone gamma-carboxyglutamate protein 2 (Bglap2) and collagen led (Canal). Furthermore, it had a significant effect on key players in energy metabolism, in particular leptin and adiponectin tibia receptors. Overall, in addition to the weight loss promoting properties of calcium, on its own or co-supplemented with CIA, our results support beneficial effects on bone metabolism in mice. (C) 2015 Published by Elsevier Inc.
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