期刊
DEPRESSION AND ANXIETY
卷 29, 期 5, 页码 449-459出版社
WILEY
DOI: 10.1002/da.21892
关键词
fMRI; PTSD; pediatric; emotion; faces
资金
- National Institute of Mental Health [MH63893]
- National Association for Research in Schizophrenia and Depression (NARSAD)
- American Foundation for Suicide Prevention (AFSP)
- Evans Foundation
- Klingenstein Third Generation Foundation
Objective This study examined activation to facial expressions in youth with a history of interpersonal trauma and current posttraumatic stress symptoms (PTSS) compared to healthy controls (HC). Design and analysis Twenty-three medication-naive youth with PTSS and 23 age- and gender-matched HC underwent functional magnetic resonance imaging (fMRI) while viewing fearful, angry, sad, happy, and neutral faces. Data were analyzed for group differences in location of activation, as well as timing of activation during the early versus late phase of the block. Using SPM5, significant activation (P < .05 FWE [Family-Wise Error] corrected, extent = 10 voxels) associated with the main effect of group was identified. Activation from selected clusters was extracted to SPSS software for further analysis of specific facial expressions and temporal patterns of activation. Results The PTSS group showed significantly greater activation than controls in several regions, including the amygdala/hippocampus, medial prefrontal cortex, insula, and ventrolateral prefrontal cortex, and less activation than controls in the dorsolateral prefrontal cortex (DLPFC). These group differences in activation were greatest during angry, happy, and neutral faces, and predominantly during the early phase of the block. Post hoc analyses showed significant Group x Phase interactions in the right amygdala and left hippocampus. Conclusions Traumatic stress may impact development of brain regions important for emotion processing. Timing of activation may be altered in youth with PTSS.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据