期刊
DENTAL MATERIALS
卷 30, 期 1, 页码 16-32出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dental.2013.08.201
关键词
Biodegradation; Resin composites; Streptococcus mutans; Matrix metalloproteinase (MMPs); Dental restorative materials; Bacteria; Esterases; Hydrolysis; Resin adhesives; Toxicity
资金
- National Sciences and Engineering Research Council of Canada (NSERC) [360520]
Objective. To survey the recent literature from the late 1980s to recent years in order to assess the relationship between resin degradation, catalyzed by biological factors, and clinical failure outcomes such as marginal breakdown. Methods. The literature shows that degradation occurs in many manufacturers' products despite varied vinyl acrylate compositions. The authors examine salivary enzyme activity and their ability to degrade the polymeric matrix of resin composites and adhesives, as well as oral microorganisms that can promote demineralization of the tooth surface at the marginal interface. A survey of recent research relating matrix metalloproteinase (MMPs) to the degradation of the exposed collagen at the dentin adhesive interface is also discussed in the context of marginal breakdown. Results. The literature provides strong support that together, the above factors can breakdown the marginal interface and limit the longevity of resin composite restorations. The authors have found that the field's current understanding of resin biodegradation in the oral cavity is just beginning to grasp the role of bacteria and enzymes in the failure of resin-based restorations. Significance. Knowledge of these biodegradation processes is pertinent to areas where innovative strategies in the chemistry of restorative materials are anticipated to enhance the longevity of resin composites. (C) 2013 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
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