期刊
DENTAL MATERIALS
卷 27, 期 11, 页码 1135-1143出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dental.2011.08.007
关键词
Acrylic resins; Autopolymerization; Degree of conversion; FTIR; Residual monomer; Residual methyl methacrylate; HPLC; Biocompatibility; Cytotoxicity; XTT
资金
- Research Support Unit of Istanbul University [T-412/08032004]
Objectives. This study evaluated the effect of post-polymerization heat-treatments on degree of conversion (DC), residual methyl methacrylate concentration (MMAr) and in vitro cytotoxicity of autopolymerizing acrylic repair resin. Methods. A total of 336 specimens were prepared by bench-and hydroflask-curing and subjected to post-polymerization heat-treatments: a) water immersion at 60 degrees C for 30 min, b) microwaving at 500 W for 3 min, c) combined use of water immersion and microwaving d) no treatment (as control). Specimens were eluted in cell culture medium for 1, 2, 5 and 7 days. DC and MMAr in eluates were measured by FTIR spectrometry and HPLC, respectively. In vitro cytotoxicity of eluates on L-929 fibroblasts was determined by XTT assay. Data were statistically analyzed with Dunn's multiple comparison and Pearson correlation tests (p <= 0.05). Results. DC was highest (99.9%) in bench-and hydroflask-cured groups which were subjected to water immersion. At all elution periods, MMAr was detected in eluates of all treatment groups and were higher in bench-cured groups than hydro-flask cured groups. Cell proliferation values indicated slightly cytotoxic effect throughout 7 days; regardless of the curing method or post-polymerization treatment. The correlation between MMAr and cell proliferation was negative after elution of 1, 2, 5 days and was only statistically significant (p < 0.05) at 5 days. At elution of 7 days, the correlation was positive with no significance. Significance. Post-polymerization heat-treatment of autopolymerizing acrylic repair resin by immersion in water at 60 degrees C for 30 min is clinically recommended to improve the DC while reducing the leaching residual MMA. (C) 2011 Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.
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