期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 38, 期 5-6, 页码 337-346出版社
KARGER
DOI: 10.1159/000362265
关键词
Metabolic syndrome; Cognition; Cognitive decline; Obesity; Hypertension; Dementia
资金
- National Heart, Lung, and Blood Institute contracts [HHSN 268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, HHSN268201100012C]
Background: Midlife metabolic syndrome (MetS) may impact cognitive health as a construct independently of hypertension, hyperlipidemia and other components. Methods: 10,866 participants aged 45-64 years at baseline were assessed for MetS and completed cognitive testing at two later time points (3 and 9 years from the baseline visit). Results: MetS is associated with increased odds of low cognitive performance in the domains of executive function and word fluency, but not with 6-year cognitive decline. Individual MetS components explained this association (hypertension, diabetes, low HDL, elevated triglycerides and increased waist circumference). Conclusions: A focus on the individual risk factors as opposed to MetS during midlife is important to reduce the incidence of cognitive impairment in later life. (C) 2014 S. Karger AG, Basel
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