期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 34, 期 2, 页码 135-141出版社
KARGER
DOI: 10.1159/000342347
关键词
Primary progressive aphasias; Alzheimer's disease; Cognitive assessment; Longitudinal assessment; Rating scale; Dementia staging
资金
- ARC Centre of Excellence in Cognition and its Disorders [CE110001021]
- NHMRC Early Career Fellowship [1016399]
- Australian Research Council Federation Fellowship [FF0776229]
- Chilean Government
Background/Aims: The longitudinal course of three primary progressive aphasia (PPA) variants was examined using Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Frontotemporal dementia Rating Scale (FRS). Methods: Cases with two assessments on the ACE-R and FRS were selected. A total of 220 assessments were obtained on 55 patients: 17 Alzheimer's disease (AD) and 38 PPA [17 semantic variant (svPPA), 12 non-fluent/agrammatic (naPPA) and 9 logopenic variant (lvPPA) cases]. Results: The annualized rate of change was greater in all PPA variants in comparison with the AD group on the ACE-R whereas only the svPPA and naPPA groups differed from AD on the FRS. Conclusions: The longitudinal profile differs across PPA syndromes on cognitive and functional measures. Findings have theoretical implications and are relevant to the care of patients with dementia. Copyright (C) 2012 S. Karger AG, Basel
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