期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 32, 期 2, 页码 79-93出版社
KARGER
DOI: 10.1159/000330757
关键词
Cerebrospinal fluid; Delirium; Neurotransmitters; Cytokines; Cortisol; Biomarkers
资金
- Research into Ageing
- British Geriatrics Society
- MRC
- Medical Research Council [G0700704B, G108/646] Funding Source: researchfish
- MRC [G108/646] Funding Source: UKRI
Background: Cerebrospinal fluid (CSF) analysis has great potential to advance understanding of delirium pathophysiology. Methods: A systematic literature review of CSF studies of DSM or ICD delirium was performed. Results: In 8 studies of 235 patients, delirium was associated with: elevated serotonin metabolites, interleukin-8, cortisol, lactate and protein, and reduced somatostatin, beta-endorphin and neuron-specific enolase. Elevated acetylcholinesterase predicted poor outcome after delirium and higher dopamine metabolites were associated with psychotic features. Conclusions: No clear conclusions emerged, but the current literature suggests multiple areas for further investigation with more detailed studies. Copyright (C) 2011 S. Karger AG, Basel
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