期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 27, 期 5, 页码 429-438出版社
KARGER
DOI: 10.1159/000214632
关键词
Mini-Mental State Examination; Free and Cued Reminding Selective Test; Episodic memory; Neuropsychological tests
资金
- Fondation pour la Recherche Medicale
- Caisse Nationale Maladie des Travailleurs Salaries
- Direction Generale de la Sante
- MGEN
- Institut de la Longevite
- Conseils Regionaux of Aquitaine and Bourgogne
- Fondation de France
- Ministry of Research - Inserm Programme
Background/Aims: Episodic memory impairment is known to be the core of Alzheimer's disease (AD) dementia syndrome and one of the earliest domains to decline. However, episodic memory tests are long and expensive. Methods: In a sample of the French Three-City Study (n = 1,516), we aimed at validating a subtest of the Mini-Mental State Examination (MMSE) specifically measuring episodic memory. We focused on the correlation between 7 MMSE subscores and 4 scores of the Free and Cued Selective Reminding Test (FCSRT) evaluating episodic memory. We performed linear regressions and principal component analyses to identify which MMSE subscores were better correlated with the FCSRT scores. Thereafter, we conducted validation analyses on the whole sample (n = 9,077). Results: We found that subscores for orientation to time and the 3-word recall task were well correlated with FCSRT scores. The summation of these 2 subscores was more strongly associated with dementia and AD than the FCSRT scores and the total MMSE score. Conclusion: Orientation to time and the 3-word recall task might provide a good measure of episodic memory. Making the evaluation of episodic memory faster and cheaper, this finding can be of direct interest for practitioners and epidemiologists. Copyright (C) 2009 S. Karger AG, Basel
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