期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 28, 期 1, 页码 47-55出版社
KARGER
DOI: 10.1159/000229025
关键词
Mild cognitive impairment; Alcohol; Hypertension; BMI; Depression
资金
- NHMRC of Australia Unit [973302, 179805]
- NHMRC project [157125]
- Australian Rotary Health Research Fund
- Australian Brewers Foundation
- Alzheimer's Australia Research
- Centre for Mental Health Research at the Australian National University
- NHMRC Research Fellowship [366756]
Aims: The aim of this study was to identify physical and mental health and lifestyle predictors of transition from normal cognition to mild cognitive disorder (MCD). Methods: A total of 2,082 individuals, aged 60-64 years, were assessed at 2 time-points 4 years apart for mild cognitive impairment (MCI) and other MCDs. Results: The main predictors of conversion to MCI and to other mild cognitive disorders were past alcohol intake, current anxiety and depression medication, increased systolic blood pressure, and past smoking. Conclusion: Participants with a history of smoking or harmful alcohol consumption, hypertension, or who took medication for anxiety or depression were at increased risk of transitioning to MCI or any MCD. Strategies targeted at managing the above risk factors may have benefits in preventing mild cognitive decline in relatively healthy middle-aged individuals living in the community. Copyright (c) 2009 S. Karger AG, Basel
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