期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 28, 期 4, 页码 281-287出版社
KARGER
DOI: 10.1159/000245156
关键词
Alzheimer's disease; Inflammation; Cytokines; Chemokines; Biomarkers
资金
- Ministry of Health and Welfare, Republic of Korea [A050079]
- GSK Korea
A chronic inflammatory process has been implicated in the neuropathology of Alzheimer's disease (AD). The present review focuses on the current knowledge of circulating serum and plasma biomarkers of AD that are linked to inflammatory reactions. There is abundant evidence that inflammatory mechanisms within the central nervous system contribute to cognitive impairment via cytokine-mediated interactions between neurons and glial cells. Interleukins 1, 4, 6, 10, 12, 16, and 18, tumour necrosis factor, and several chemokines have been suggested as biomarkers of AD. Nonetheless, data on circulating cytokine levels are somewhat inconsistent with regard to peripheral cytokine dysregulation in AD. In summary, definite statements concerning differences in inflammatory biomarkers between controls and AD patients will require the use of sensitive multiplex assays in large patient groups in conjunction with measures of disease severity. Copyright (c) 2009 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据