期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 25, 期 3, 页码 278-286出版社
KARGER
DOI: 10.1159/000118633
关键词
Alzheimer's disease; vascular dementia; mixed dementia; pro-inflammatory and anti-inflammatory cytokines
资金
- MRC [G0400074, G0500247, G0502157] Funding Source: UKRI
- Medical Research Council [G0400074, G0500247, G0502157] Funding Source: Medline
- Alzheimers Research UK [ART-PPG2005A-5] Funding Source: researchfish
Vascular dementia (VaD) accounts for about 20% of all dementias, and vascular risk is a key factor in more than 40% of people with Alzheimer's disease (AD). Little is known about inflammatory processes in the brains of these individuals. We have examined inflammatory mediators (interleukin ( IL)-1 beta, IL-1 alpha, IL-6 and tumour necrosis factor alpha) and chemokines (macrophage inflammatory protein 1, monocyte chemo-attractant protein (MCP)-1 and granulocyte macrophage colonystimulating factor) in brain homogenates from grey and white matter of the frontal cortex (Brodmann area 9) from patients with VaD (n = 11), those with concurrent VaD and AD (mixed dementia; n = 8) and from age-matched controls (n = 13) using ELISA assays. We found a dramatic reduction of MCP-1 levels in the grey matter in VaD and mixed dementia in comparison to controls (55 and 66%, respectively). IL-6 decreases were also observed in the grey matter of VaD and mixed dementia (72 and 71%, respectively), with a more modest decrease (30%) in the white matter of patients with VaD or mixed dementia. In the first study to examine the sta tus of inflammatory mediators in a brain region severely affected by white-matter lesions, our findings highlight - in contrast to previous reports in AD - that patients at the later stage of VaD or mixed dementia have a significantly attenuated neuro-inflammatory response. Copyright (c) 2008 S. Karger AG, Basel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据