期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 27, 期 1, 页码 1-10出版社
KARGER
DOI: 10.1159/000182420
关键词
Aging; Alzheimer's disease; APOE; Compensation; Dedifferentiation; Dementia; Functional magnetic resonance imaging; Functional neuroimaging; Region-Activation-Performance model (RAP model)
资金
- National Institutes of Health [F31 NS059193, K24 AG026431, P50 AG005131, RO1 AG012674, IIRG-07-59343]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [F31NS059193] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P50AG005131, K24AG026431, R01AG012674] Funding Source: NIH RePORTER
There has been a recent proliferation of functional magnetic resonance imaging ( fMRI) studies that interpret between-group or within-group differences in brain response patterns as evidence for compensatory neural recruitment. However, it is currently a challenge to determine whether these observed differences are truly attributable to compensatory neural recruitment or whether they are indicative of some other cognitive or physiological process. Therefore, the need for a standardized set of criteria for interpreting whether differences in brain response patterns are compensatory in nature is great. Focusing on studies of aging and potentially prodromal Alzheimer's disease conditions ( genetic risk, mild cognitive impairment), we critically review the functional neuroimaging literature purporting evidence for compensatory neural recruitment. Finally, we end with a comprehensive model set of criteria for ascertaining ported. This proposed model addresses significant brain region, activation pattern, and behavioral performance considerations, and is therefore termed the Region-Activation-Performance model (RAP model). Copyright (c) 2008 S. Karger AG, Basel
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