期刊
JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS
卷 8, 期 1, 页码 44-53出版社
KARGER
DOI: 10.1159/000431151
关键词
Genome-wide analysis study; Total fat intake; Low-density lipoprotein peak particle size; Nutrigenetics; Single nucleotide polymorphisms
资金
- Canadian Institute of Health Research (CIHR) [FRN-CCT-83028]
- Sanofi Aventis
- John W. Barton Sr, Chair in Genetics and Nutrition
Background/Aim: Total fat intake has an important impact on the low-density lipoprotein (LDL) peak particle diameter (LDL-PPD) and may interact with nutrient-sensitive single nucleotide polymorphisms (SNPs). The objective was to examine whether there is suggestive evidence of SNP x dietary fat intake interaction effects influencing the LDL-PPD in the Quebec Family Study (QFS) in order to generate hypotheses to be tested in larger studies. Methods: SNPs from a genome-wide association study (GWAS) using Illumina Human610-Quad Bead-Chip, total fat intake derived from a 3-day weighted food record, and SNP x total fat intake interaction effects were examined on LDL-PPD in 541 QFS subjects. Results: The GWAS analyses 29 identified independent SNP x total fat intake interaction effects on the LDL-PPD at p < 10(-5), including SNPs in the following genes: ABCG2, CPA3, FNBP1, KCNQ3, NBAS, NCALD, OPRL1, NKAIN2, SH3BGRL2, SOX5, and SUSD4. Conclusions: This observational study suggests that multiple SNPs interact with dietary fat intake to influence variation in the LDL-PPD. (C) 2015 S. Karger AG, Basel
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