期刊
DALTON TRANSACTIONS
卷 43, 期 13, 页码 4941-4944出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3dt52828f
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资金
- Grants-in-Aid for Scientific Research [24102526, 26102721, 25810104] Funding Source: KAKEN
Diaryl-substituted ortho-carboranes 1 were synthesized from the corresponding alkynes by decaborane coupling under microwaveirradiated conditions with a combination of N,N-dimethylaniline and chlorobenzene. Among the compounds synthesized, 1a and 1d exhibited significant inhibition of hypoxia-induced HIF-1 transcriptional activity. Both compounds similarly suppressed hypoxia-induced HIF-1 alpha accumulation in a concentration-dependent manner without affecting HIF-1 alpha mRNA expression.
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