期刊
DALTON TRANSACTIONS
卷 43, 期 14, 页码 5535-5545出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3dt53095g
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资金
- CRUK
- EPSRC
- MRC
- Department of Health [C2536/A10337]
- MRC [MC_U120081322] Funding Source: UKRI
- Cancer Research UK [10337] Funding Source: researchfish
- Medical Research Council [MC_U120081322] Funding Source: researchfish
A series of new upconversion nanoparticles have been functionalised with tumour-targeting molecules and metal chelates, prepared following standard peptidic and thiol chemistry. The targeting strategy has been delivered via the alpha(v)beta(3) integrin, which is a heterodimeric cell surface receptor that is up-regulated in a variety of cancers, such as melanoma and breast cancer. The well-known DOTA (1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid) motif allows coordination to the radionuclide Ga-68. Radiolabelling experiments were optimised under relatively mild conditions, and are rare amongst nanoparticulate materials. In vivo application of these probes in mouse tumour models revealed their potential as specific cancer contrast agents for PET imaging.
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