期刊
DALTON TRANSACTIONS
卷 43, 期 35, 页码 13343-13348出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt01572j
关键词
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资金
- National Natural Science Foundation of China [51102202]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20114301120006]
- Hunan Provincial Natural Science Foundation of China [12JJ4056]
- Scientific Research Fund of Hunan Provincial Education Department [13B062]
Polyethylene glycol (PEG) modified BaLuF5:Gd/Yb/Er upconversion nanoparticles (UCNPs) were synthesized by a facile one-pot hydrothermal method for simultaneous synthesis and surface functionalization. The novel, excellently biocompatible and water-soluble bioprobes were used for simultaneous upconversion (UC) luminescence and X-ray bioimaging for the first time. The as-prepared BaLuF5:Gd/Yb/Er UCNPs possess a face-centered cubic structure with an average size of 23.7 +/- 2.7 nm. Under 980 nm laser excitation, these UCNPs emitted intense UC luminescence via a two-photon process. In vitro bioimaging and localized luminescence spectra detected from HeLa cells and the background reveal that these UCNPs are ideal candidates for optical bioimaging in the absence of autofluorescence. Furthermore, the synergistic in vivo UC luminescence and X-ray bioimaging reveal that these PEG-modified BaLuF5:Gd/Yb/Er UCNPs can be successfully used as ideal dual-modal bioprobes. These results demonstrate that these PEG modified UCNPs are ideal multi-modal nanoprobes for bioimaging.
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