期刊
DALTON TRANSACTIONS
卷 43, 期 30, 页码 11709-11715出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4dt00424h
关键词
-
资金
- National Natural Science Foundation of China [51302035, 21171035]
- Key Grant Project of Chinese Ministry of Education [313015]
- Ph.D. Programs Foundation of Ministry of Education of China [20110075110008]
- National 863 Program of China [2013AA031903]
- Fundamental Research Funds for the Central Universities
- Science and Technology Commission of Shanghai Municipality [13ZR1451200]
- Hong Kong Scholars Program
- China Postdoctoral Science Foundation
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1221]
- Shanghai Leading Academic Discipline Project [B603]
- Program of Introducing Talents of Discipline to Universities [111-2-04]
The semiconductor compounds have been proven to be promising candidates as a new type of photothermal therapy agent, but unsatisfactory photothermal conversion efficiencies limit their widespread application in photothermal therapy (PTT). Herein, we synthesized cysteine-coated CuS nanoparticles (Cys-CuS NPs) as highly efficient PTT agents by a simple aqueous solution method. The Cys-CuS NPs have a good biocompatibility owing to their biocompatible cysteine coating and exhibit a strong absorption in the near-infrared region due to the localized surface plasma resonances of valence-band free carriers. The photothermal conversion efficiency of Cys-CuS NPs reaches 38.0%, which is much higher than that of the recently reported Cu9S5 and Cu2-xSe nanocrystals. More importantly, tumor growth can be efficiently inhibited in vivo by the fatal heat arising from the excellent photothermal effect of Cys-CuS NPs at a low concentration under the irradiation of a 980 nm laser with a safe power density of 0.72 W cm(-2). Therefore, the Cys-CuS NPs have great potential as ideal photothermal agents for cancer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据