期刊
ANNALES D ENDOCRINOLOGIE
卷 76, 期 3, 页码 253-259出版社
MASSON EDITEUR
DOI: 10.1016/j.ando.2015.03.008
关键词
Distilbene (R); Vaginal adenocarcinoma; Hypospadias; Fetal exposure; Endocrine disruptors; Transgenerational effect
The Distilbene (R) story is a dramatic episode which belongs to the history of medicine. It provided several useful lessons such as the importance of evidence-based medicine and the hazard to develop treatments during pregnancy without careful animal verifications. However, this experience has also provided unexpected progress by suggesting new pathophysiological concepts: fetal programming of adult diseases and/or transgenerational transmission of environmental effects through epigenetic modifications. (C) 2015 Published by Elsevier Masson SAS.
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