期刊
JOURNAL OF NUCLEAR MEDICINE
卷 56, 期 8, 页码 1199-1205出版社
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.114.152405
关键词
amyloid; blood flow; PiB PET; Alzheimer's disease; kinetic modeling
资金
- NCATS NIH HHS [UL1 TR000005] Funding Source: Medline
- NIA NIH HHS [R01AG033042, K02 AG027998, RF1 AG025516, P50AG005133, R37AG025516, K02AG027998, R01 AG033042, R37 AG025516, P01 AG025204, P50 AG005133, P01AG025204] Funding Source: Medline
- NIMH NIH HHS [R01MH070729, R01 MH070729] Funding Source: Medline
The primary goal of this study was to assess the suitability of C-11-Pittsburgh compound B (C-11-PiB) blood-brain barrier delivery (K-1) and relative delivery (R-1) parameters as surrogate indices of cerebral blood flow (CBF), with a secondary goal of directly examining the extent to which simplified uptake measures of C-11-PiB retention (amyloid-beta load) may be influenced by CBF, in a cohort of controls and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). Methods: Nineteen participants (6 controls, 5 AD, 8 MCI) underwent MR imaging, O-15-water PET, and C-11-PiB PET in a single session. Fourteen regions of interest (including cerebellar reference region) were defined on MR imaging and applied to dynamic coregistered PET to generate time-activity curves. Multiple analysis approaches provided regional O-15-water and C-11-PiB measures of delivery and C-11-PiB retention that included compartmental modeling distribution volume ratio (DVR), arterial- and reference-based Logan DVR, simplified reference tissue modeling 2 (SRTM2) DVR, and standardized uptake value ratios. Spearman correlation was performed among delivery measures (i.e., O-15-water K-1 and C-11-PiB K-1, relative K-1 normalized to cerebellum [Rel-K1-Water and Rel-K1-PiB], and C-11-PiB SRTM2-R-1) and between delivery measures and C-11-PiB retention, using the Bonferroni method for multiple-comparison correction. Results: Primary analysis showed positive correlations (rho approximate to 0.2-0.5) between O-15-water K-1 and C-11-PiB K-1 that did not survive Bonferroni adjustment. Significant positive correlations were found between Rel-K1-Water and Rel-K1-PiB and between Rel-K1-Water and C-11-PiB SRTM2-R-1 (rho approximate to 0.5-0.8, P < 0.0036) across primary cortical regions. Secondary analysis showed few significant correlations between C-11-PiB retention and relative C-11-PiB delivery measures (but not O-15-water delivery measures) in primary cortical areas that arose only after accounting for cerebrospinal fluid dilution. Conclusion: C-11-PiB SRTM2-R-1 is highly correlated with regional relative CBF, as measured by O-15-water K-1 normalized to cerebellum, and cross-sectional C-11-PiB retention did not strongly depend on CBF across primary cortical regions. These results provide further support for potential dual-imaging assessments of regional brain status (i.e., amyloid-beta load and relative CBF) through dynamic C-11-PiB imaging.
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