期刊
DALTON TRANSACTIONS
卷 40, 期 33, 页码 8328-8334出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1dt10338e
关键词
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资金
- EPSRC
- Alfama
- Hemocorm
[Fe(L-cysteinate)(2)(CO)(2)](2-) is a CO releasing molecule which has low cytotoxicity to RAW264.7 macrophages. It provides an example of CO binding using ligands available to ion channels which use CO as a signalling molecule in the absence of heme. Previous work has shown that this compound consists of five isomers and it was proposed that the two isomers with trans-dicarbonyls are dominant. In this work the isomers are re-assigned and shown to be capable of releasing CO, albeit too slowly to act as a signalling receptor. It is shown that by linking the two L-cysteines together to form [Fe(SCH2CH{CO2H}NHCH2)(2)(CO)(2)], only one isomer is isolated.
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