期刊
DALTON TRANSACTIONS
卷 39, 期 18, 页码 4435-4439出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b925779a
关键词
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资金
- Science and Technology Commission of Shanghai [0852nm05800, 1052nm06200]
- Program of Shanghai Subject Chief Scientist [07XD14031]
- National Natural Science Foundation of China [50772124, 50821004]
- Shanghai Institute of Ceramics [SCX0606]
We report room-temperature preparation of poly(ethylene glycol)-block-polylactide (PEG-PLA)/calcium phosphate (CP) nanocomposites with a porous morphology. The reaction time and concentration of the inorganic ingredients play an important role in the morphology and chemical composition of the nanocomposite. Thermogravimetry analysis shows that there is approximately 8.5 wt.% of PEG-PLA block copolymer in the nanocomposite. A typical anti-inflammatory drug, ibuprofen, is used to evaluate the drug loading ability and the release behavior of the porous PEG-PLA/CP nanocomposite. The experiments reveal that the nanocomposite has a higher drug loading capacity and favorable drug release property. The drug release kinetics of the porous PEG-PLA/CP nanocomposite is discussed as a three-stage process. The as-prepared porous PEG-PLA/CP nanocomposite is promising for application in drug delivery.
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