期刊
DALTON TRANSACTIONS
卷 39, 期 31, 页码 7345-7352出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c003085f
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资金
- Higher Education Commission of Pakistan
- Austrian Exchange Service (OAD)
- Hochschuljubilaumsstiftung Vienna
- Theodor-Korner-Fonds
- FFG - Austrian Research Promotion Agency [811591]
- Austrian Council for Research and Technology Development [IS526001]
- COST [D39, CM0902]
- Austrian Science Fund
- Marie Curie Intra European [220890-SuRuCo]
The synthesis and in vitro anticancer activity of Os-II-arene complexes with carbohydrate-derived phosphite co-ligands are reported. The compounds were characterized by standard methods and the molecular structure of dichlorido(eta(6)-p-cymene)(3,5,6-bicyclophosphite-1,2-O-isopropylidene-alpha-D-glucofuranoside) osmium(II) was determined by X-ray diffraction analysis. Complexes with chlorido leaving groups undergo hydrolysis by consecutive formation of aqua compounds, followed by cleavage of a P-O bond of sugar phosphite ligands, as demonstrated by NMR studies. These observations are similar to those of analogous Ru-II-arene complexes; however the rate of hydrolysis is very slow for osmium compounds. The complexes with oxalato leaving groups resist hydrolysis; no hydrolytic species were detected by P-31{H-1} NMR spectroscopy over several days. Within this series of Os compounds, in vitro anticancer activity is highest for the most lipophilic chlorido complex dichlorido(eta(6)-p-cymene)(3,5,6-bicyclophosphite-1,2-O-cyclohexylidene-alpha-D-glucofuranoside) osmium(II).
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