期刊
DALTON TRANSACTIONS
卷 -, 期 6, 页码 918-921出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b816249b
关键词
-
资金
- University of Greenwich
- GRE
The Knoevenagel condensation of 1,3-dihydro-2H-indol-2-one 1 with ferrocene carboxaldehyde 2 afforded an approximate 2: 1 mixture of the geometrical isomers (E)- and (Z)-3-ferrocenylmethylidene-1,3-dihydro-2H-indol-2-one 3 respectively in an overall 67% yield; the air and solution-stable isomers were readily separated by preparative thin layer chromatography and their structures were unequivocally elucidated in solution, by H-1 NMR spectroscopy, and in the solid phase, by X-ray crystallography; both isomers of 3 displayed in vitro toxicity against B16 melanoma and Vero cell lines in the micromolar range and inhibited the kinase VEGFR-2 with IC50 values of ca. 200 nM.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据