期刊
DALTON TRANSACTIONS
卷 -, 期 5, 页码 800-804出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b809645g
关键词
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资金
- MEC [CTQ2006-02840, FQM2007-02525]
- PRIN [2005039758]
- European project NoE MAGMANET [NMP3-CT-2005 515767]
- University of Milano [FIRST-2006, FIRST-2007]
We have prepared water-soluble gadolinium oxide nanoparticles that show potential as MRI contrast agents. The particles were built into the apoferritin cavity and have an average size of 5 nm. After seven days a loss of 5% of Gd was detected compared with the as-prepared samples; after that the Gd remained constant and stabilized inside the apoferritin, indicating that the apoferritin capsid acts as a Gd store, avoiding metal delivery and consequent toxicity. The NMR longitudinal and transverse relaxivities resulted about 10 and 70 times higher than the ones of clinically approved paramagnetic Gd-chelates, thus indicating the possible route for synthesizing a novel class of MRI contrast agents.
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