期刊
DALTON TRANSACTIONS
卷 -, 期 2, 页码 262-272出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b813363h
关键词
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资金
- 973 Project [2007CB516805]
- National Natural Science Foundation of China [30460153, 20361002, 20861002]
- Natural Science Foundation of Guangxi Province [0429001, 0575049, 0542001]
- Program for New Century Excellent Talents in University of Chinese Ministry of Education [NCET-04-0836]
- Project of Ten, Hundred, Thousand Distinguished Talents in New Century of Guangxi [2003223]
- Key Project of Chinese Ministry of Education [03101, 204111]
Liriodenine (L), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (1), cis-[PtCl2(L)(DMSO)] (2), and cis-[RuCl2(L)(DMSO)(2)]center dot 1.5H(2)O (3), the crystal structures of L, 2 and 3 were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, H-1 and C-13 NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of L and complexes 1-3 against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free L, suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of L and its complexes 1-3 to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.
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