期刊
CYTOTHERAPY
卷 16, 期 12, 页码 1692-1699出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcyt.2014.07.012
关键词
B cells; chemotaxis; mesenchymal stromal cells; migration
类别
资金
- Spanish Ministry of Economy and Competitiveness (MINECO) [BFU2008-01194, BFU2011-30097]
- Spanish MINECO [BFU2011-30097]
- European Union [279174]
Background aims. Mesenchymal stromal cells hold special interest for cell-based therapy because of their tissue-regenerative and immunosuppressive abilities. B-cell involvement in chronic inflammatory and autoimmune pathologies makes them a desirable target for cell-based therapy. Mesenchymal stromal cells are able to regulate B-cell function; although the mechanisms are little known, they imply cell-to-cell contact. Methods. We studied the ability of human adipose tissue-derived mesenchymal stromal cells (ASCs) to attract B cells. Results. We show that ASCs promote B-cell migration through the secretion of chemotactic factors. Inflammatory/innate signals do not modify ASC capacity to mediate B-cell motility and chemotaxis. Analysis of a panel of B cell-related chemokines showed that none of them appeared to be responsible for B-cell motility. Other ASC-secreted factors able to promote cell motility and chemotaxis, such as the cytokine interleukin-8 and prostaglandin E-2, did not appear to be implicated. Conclusions. We propose that ASC promotion of B-cell migration by undefined secreted factors is crucial for ASC regulation of B-cell responses.
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