期刊
CYTOTHERAPY
卷 14, 期 2, 页码 240-246出版社
INFORMA HEALTHCARE
DOI: 10.3109/14653249.2011.627918
关键词
adipose-derived stem cells; active and quiescent stem cells; vascular stem cells
类别
资金
- Arthur Rock Foundation
- National Institutes of Health [DK64538, DK045370, DK069655]
Background aims. Recent studies have demonstrated the existence of both active and quiescent stem cells in bone marrow, hair follicle and intestine. We attempted to identify active and quiescent vascular stromal cells (VSC) in adipose tissue. Methods. For identification of active VSC, adult rats were injected intraperitoneally with thymidine analog 5-ethynyl-2-deoxyuridine (EdU) and their subcutaneous tissue harvested 3 days later. For identification of quiescent VSC, newborn rats were injected intraperitoneally with EdU and their subcutaneous tissue harvested 9 weeks later. The harvested adipose tissues were examined for the co-localization of EdU with VSC marker CD34, smooth muscle marker SMA, endothelial marker RECA and pericyte marker CD140b. Results. In adult rat adipose tissues harvested 3 days after EdU injection, there were 28.80 +/- 8.70 (mean +/- SD) EdU
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