期刊
CYTOTECHNOLOGY
卷 70, 期 6, 页码 1585-1594出版社
SPRINGER
DOI: 10.1007/s10616-018-0251-3
关键词
Rhaponticum carthamoides; Caffeoylquinic acid derivatives; Transformed roots; Glioma cells; PARP1 cleavage; H2A; X phosphorylation
资金
- Medical University of Lodz, Poland [503/3-012-01/503-31-001-17]
Rhaponticum carthamoides transformed root extract induces double strand DNA damage by increasing the number of phosphorylated H2A.X- and cleaved PARP1-positive U87MG cells and patient-derived IV grade glioma cells. Furthermore, treatment of these cells with root extract causes down-regulation of UHRF1 and DNMT1. Transformed root extract is rich in caffeoylquinic acid derivatives, especially tricaffeoylquinic acid derivatives. Our findings demonstrate that the R. carthamoides transformed root extract may trigger apoptosis in glioma cells by induction of DNA damage, PARP cleavage and epigenetic modification.
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