期刊
CYTOTECHNOLOGY
卷 68, 期 3, 页码 389-397出版社
SPRINGER
DOI: 10.1007/s10616-014-9790-4
关键词
Oridonin; Migration; Myosin IIA; Regulatory light chain; Phosphatase complex
资金
- National Natural Science Foundation of China (NSFC) [81172961]
Oridonin, which is isolated from Chinese herb Rabdosia rubescens (Hemsl.) Hara, has been implicated in regulation of tumor cell migration and invasion. In this study, treatment with oridonin enhanced the phosphorylation of myosin regulatory light chain (T18/S19) that regulates the ATPase activity of myosin IIA. Meanwhile, stress fibers were significantly more prominent after oridonin incubation, which impaired cell migration in transwell migration assays. All of these effects may be caused by the decreased interaction between myosin IIA and myosin phosphatase complex, but not kinases. Our data provide clear evidence of this novel pharmacological function for oridonin in treating cancer cell migration.
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