期刊
CYTOSKELETON
卷 69, 期 7, 页码 506-513出版社
WILEY
DOI: 10.1002/cm.21019
关键词
cytosolic synaptic proteins; synapsin; alpha-synuclein; slow axonal transport; transport packets; cargo complexes; diffusion; slow component-b; SCb
类别
资金
- March Of Dimes
- NIH [R01NS075233]
Slow axonal transport conveys perikaryally-synthesized cytosolic proteins in a rate-class called Slow Component-b (SCb). One such protein-alpha-synuclein-is largely conveyed in SCb, and is also a key player in a group of neurodegenerative diseases called synucleinopathies. Axonal transport defects of alpha-synuclein have been hypothesized to play a role in synucleinopathies, but mechanisms moving alpha-synuclein in slow axonal transport are unclear. Here we use a recently developed model-system in our laboratory to visualize the slow transport of alpha-synuclein, comparing it to another SCb protein synapsin. Despite differences inbiological properties and overall-solubility in axons, the anterograde transport of both SCb proteins was strikingly similar, suggesting commonalities in slow axonal transport mechanisms of seemingly diverse cytosolic cargoes. The data support a model where SCb proteins dynamically organize into 'transport-competent' complexes that are conveyed via transient associations with other persistently-moving cargoes (mobile-units). The identity of the latter is yet unknown. Visualizing normal a-synuclein transport may also open the door to studies of a-synuclein transport in pathologic states. (C) 2012 Wiley Periodicals, Inc
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