期刊
CYTOSKELETON
卷 68, 期 11, 页码 603-618出版社
WILEY-BLACKWELL
DOI: 10.1002/cm.20540
关键词
microtubule; microtubule-end-binding proteins; +TIPs; cell polarity; morphogenesis
类别
资金
- Takeda Science Foundation
- Kurata Memorial Hitachi Science and Technology Foundation
- JSPS
Microtubules serve as rails for intracellular trafficking and their appropriate organization is critical for the generation of cell polarity, which is a foundation of cell differentiation, tissue morphogenesis, ontogenesis and the maintenance of homeostasis. The microtubule array is not just a static railway network; it undergoes repeated collapse and reassembly in diverse patterns during cell morphogenesis. In the last decade much progress has been made toward understanding the molecular mechanisms governing complex microtubule patterning. This review first revisits the basic principle of microtubule dynamics, and then provides an overview of how microtubules are arranged in highly shaped and functional patterns in cells changing their morphology by factors controlling the fate of microtubule ends. (c) 2011 Wiley Periodicals, Inc.
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