期刊
CYTOSKELETON
卷 67, 期 10, 页码 609-629出版社
WILEY
DOI: 10.1002/cm.20473
关键词
protein structure; cytoskeleton; actin; actin-binding proteins; mutations; diseases
类别
资金
- Hungarian Science Foundation (OTKA) [K60968, K77840]
- Wellcome Trust
Actin is a protein abundant in many cell types. Decades of investigations have provided evidence that it has many functions in living cells. The diverse morphology and dynamics of actin structures adapted to versatile cellular functions is established by a large repertoire of actin-binding proteins. The proper interactions with these proteins assume effective molecular adaptations from actin, in which its conformational transitions play essential role. This review attempts to summarise our current knowledge regarding the coupling between the conformational states of actin and its biological function. (C) 2010 Wiley-Liss, Inc.
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