期刊
CYTOMETRY PART A
卷 79A, 期 1, 页码 77-83出版社
WILEY
DOI: 10.1002/cyto.a.20963
关键词
proline-rich peptide from Bothrops jararaca; Bj-PRO-7a; muscarinic receptor; M1 agonist
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico), Brazil [2006/61285-9]
Proline-rich peptides from Bothrops jararaca venom (Bj-PRO) were characterized based on the capability to inhibit the somatic angiotensin-converting enzyme. The pharmacological action of these peptides resulted in the development of Captopril, one of the best examples of a target-driven drug discovery for treatment of hypertension. However, biochemical and biological properties of Bj-PROs were not completely elucidated yet, and many recent studies have suggested that their activity relies on angiotensin-converting enzyme-independent mechanisms. Here, we show that Bj-PRO-7a (
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