期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 25, 期 5, 页码 597-609出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2014.06.001
关键词
KSHV; Innate immunity
资金
- National Institutes of Health [CA082057, CA31363, CA115284, CA180779, AI073099, AI105809, DE023926, HL110609]
- National Research Foundation of Korea [K20815000001]
- Hastings Foundation
- Fletcher Jones Foundation
Understanding of the innate immune response to viral infections is rapidly progressing, especially with regards to the detection of DNA viruses. Kaposi's sarcoma-associated herpesvirus (KSHV) is a large dsDNA virus that is responsible for three human diseases: Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman's disease. The major target cells of KSHV (B cells and endothelial cells) express a wide range of pattern recognition receptors (PRRs) and play a central role in mobilizing inflammatory responses. On the other hand, KSHV encodes an array of immune evasion genes, including several pirated host genes, which interfere with multiple aspects of the immune response. This review summarizes current understanding of innate immune recognition of KSHV and the role of immune evasion genes that shape the antiviral and inflammatory responses. (C) 2014 Elsevier Ltd. All rights reserved.
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