期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 25, 期 1, 页码 45-55出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2013.11.001
关键词
Celiac disease; Crohn's disease; Myofibroblast; Regulatory T cell; Smad
资金
- Ghislieri College (Pavia, Italy)
Transforming growth factor (TGF)-beta, a pleiotropic cytokine released by both immune and non-immune cells in the gut, exerts an important tolerogenic action by promoting regulatory T cell differentiation. TGF-beta also enhances enterocyte migration and regulates extracellular matrix turnover, thereby playing a crucial role in tissue remodeling in the gut. In this review we describe the mechanisms by which abnormal TGF-beta signaling impairs intestinal immune tolerance and tissue repair, thus predisposing to the onset of immune-mediated bowel disorders, such as inflammatory bowel disease and celiac disease. Additionally, we will discuss potential therapeutic strategies aiming at restoring physiologic TGF-beta signaling in chronic intestinal diseases. (c) 2013 Elsevier Ltd. All rights reserved.
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