期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 24, 期 4, 页码 373-384出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2013.05.003
关键词
Cardiovascular disease; Inflammation; Metabolism; Cancer; Neurotrophic factors
资金
- German Research Foundation (DFG)
GDF-15 (also MIC-1, NAG-1, PLAB, PTGFB) is a member of the TGF-beta superfamily, which is widely distributed in mammalian tissues and has been shown to play multiple roles in various pathologies, including inflammation, cancer, cardiovascular diseases, and obesity. GDF-15 serum levels are a highly reliable predictor of disease progression. Both the anti-tumorigenic potential of GDF-15 and its capacity to promote metastasis have been documented for a large variety of cancers, yet its opposing functions, which are typical for members of the TGF-beta superfamily, have only partly been resolved on the molecular level. Knowledge on physiological functions in the non-diseased organism is scarce. In the nervous system GDF-15 knockout analyses have revealed that GDF-15 is essential for the postnatal maintenance of various neuron populations. When applied exogenously GDF-15 is a powerful factor for promoting survival of developing and lesioned neurons in vitro and in vivo. Receptor activation by GDF- has only been partially resolved. (C) 2013 Elsevier Ltd. All rights reserved.
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