期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 23, 期 4-5, 页码 207-214出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2012.05.007
关键词
CD4 and CD8 T cell immune activation; T cell homeostasis; IL-7; Type-I IFN
资金
- Intramural NIH HHS [Z99 AI999999] Funding Source: Medline
HIV immune activation plays an important role in the immunopathogenesis of the disease. The mechanisms driving this immune activation are partially defined and likely are the result of multiple factors. The introduction of combination antiretroviral therapy (cART) has improved the life expectancy of HIV infected individuals, however there is evidence that in the setting of undetectable HIV-RNA plasma levels, there is some level of persistent immune activation in these patients. A better understanding of the immune activation pathways should be of value in developing complementary therapies to restore the immune systems of patients with HIV infection. This review discusses the cytokine mediated pathways of immune activation of the CD4 and CD8 T cell pools during HIV infection. Published by Elsevier Ltd.
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