期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 22, 期 1, 页码 1-18出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.10.011
关键词
Chemokine; Platelet factor-4 variants; CXCR3; Angiogenesis; Cancer
资金
- Fund for Scientific Research of Flanders (F.W.O-Vlaanderen)
- K.U.L. Center of Excellence Credit [EF/05/15]
- Regional Government of Flanders Concerted Research Actions
- Interuniversity Attraction Poles Program-Belgian Science Policy
- European Union [LSHB-CT-2005-518167]
Chemokines are chemotactic cytokines which recruit leukocytes to inflammatory sites. They also affect tumor development and metastasis by acting as growth factor, by attracting pro- or anti-tumoral leukocytes or by influencing angiogenesis. Platelet factor-4 (CXCL4/PF-4) was the first chemokine shown to inhibit angiogenesis. CXCL4L1/PF-4var, recently isolated from thrombin-stimulated platelets, differing from authentic CXCL4/PF-4 in three carboxy-terminally located amino acids, was found to be more potent than CXCL4/PF-4 in inhibiting angiogenesis and tumor growth. Both glycosaminoglycans (GAG) and CXCR3 are implicated in the activities of the PF-4 variants. This report reviews the current knowledge on the role of CXCL4/PF-4 and CXCL4L1/PF-4var in physiological and pathological processes. In particular, the role of CXCL4/PF-4 in cancer, heparin-induced thrombocytopenia and atherosclerosis is described. (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据