期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 22, 期 4, 页码 231-253出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2011.09.001
关键词
Haematopoiesis; Mimetics; Thrombopoietin; c-kit; c-Mpl; Stem cell factor; Notch; Jagged-1; Serrate; DII; FLT3 ligand; FLT3; Structural biology; Molecular design; Agonist; Antagonist; Growth factor; Cytokine
Blood production is a highly regulated process involving multiple inhibitory and stimulatory cytokines present in the haematopoietic stem cell niche. Small molecules mimics of these signalling molecules have substantial potential as drugs and in the development of bioreactors to generate blood products. We review the structural biology of the extracellular signalling domains of five of the most important cytokines, analyze their structure-property relationships, and summarize the progress in developing small molecule mimics using the molecular information from structural biology and mutation studies. (C) 2011 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据