期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 21, 期 5, 页码 393-401出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.09.001
关键词
IL-26; Th17 cells; IL-20R1; STAT3; Inflammation
资金
- National Institutes of Health (NIH) [AI47300, AI47300-08S]
- National Cancer Institute (NCI)
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI047300, R21AI081065] Funding Source: NIH RePORTER
IL-26 is classified as a member of the IL-10 cytokine family because it has limited sequence homology to IL-10 and the IL-10-related cytokines. The human IL-26 gene, IL26, is located on chromosome 12q15 between the genes for two other important class-2 cytokines, IFNG (IFN-gamma) and IL22 (IL-22). IL-26 is often co-expressed with IL-22 by activated T cells, especially Th17 cells. It signals through a heterodimeric receptor complex composed of the IL-20R1 and IL-10R2 chains. I1-26 receptors are primarily expressed on non-hematopoietic cell types, particularly epithelial cells. Signaling through IL-26 receptor complexes results in the activation of STAT1 and STAT3 with subsequent induction of IL-26-responsive genes. The biological functions of IL-26 have only begun to be defined. Published by Elsevier Ltd.
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