期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 21, 期 5, 页码 353-363出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.08.001
关键词
IL-20; IL-10-related cytokines; IL-20 receptor; Immune response; IL-22
资金
- Deutsche Forschungsgemeinschaft (DFG) [WE3550/4-1]
IL-20 was discovered 10 years ago as a new member of the IL-10 family of cytokines. IL-20 shares the highest amino-acid sequence identity with IL-10, IL-24 and IL-19, IL-20 is secreted by immune cells and activated epithelial cells like keratinocytes. A high expression of the corresponding IL-20 receptor chains is detected on epithelial cells. In terms of function, IL-20 might therefore mediate a crosstalk between epithelial cells and tissue-infiltrating immune cells under inflammatory conditions. Transgenic and knockout mouse models for some cytokines and receptors of the IL-10-type cytokines have provided new insights into the biology of this family. This review will focus on the biological functions of IL-20 and its receptors within the IL-10 cytokine network. (C) 2010 Elsevier Ltd. All rights reserved.
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