期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 21, 期 5, 页码 315-324出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2010.11.001
关键词
Psoriasis; Inflammatory bowel disease; RORgammaT; AHR; Interferon
LtdIn 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. Surprisingly, despite all these similarities, IL-10 family members possess different biological functions. The currently known facts regarding the biological effects of these six immune mediators give the impression that at least IL-10, IL-20, and IL-22 play an important role in the pathogenesis of some chronic inflammatory diseases. This review provides an overview of the most important and common aspects of the IL-10 family members. (C) 2010 Elsevier Ltd. All rights reserved.
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